Curr Opin Immunol. 2003 Aug;15(4):443-9.

Subversion of immune responses by hepatitis C virus: immunomodulatory strategies beyond evasion?

Source

Department of Microbiology and Beirne B. Carter Center for Immunology Research, University of Virginia, Health Sciences Center, Charlottesville 22908, USA. ysh5e@virginia.edu

Abstract

Hepatitis C virus (HCV) is an important human pathogen that causes mild to severe liver disease worldwide. This positive-strand RNA virus is remarkably efficient at establishing persistent infection. In order for a non-cytopathic virus such as HCV to persist, the virus must escape immune recognition or inhibit the host immune responses. Immune escape via mutations in antigenic sites may occur under selective pressure during B-cell or T-cell responses to HCV infection, and may serve as a mechanism for the establishment HCV persistence. In addition to antigenic variation, HCV is able to subvert the host immune response by encoding specific viral gene product(s). An understanding of the mechanisms behind HCV persistence will provide a basis for the rational design of vaccines and novel therapeutic agents targeting human HCV infection.

PMID:: 12900277; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Review Evasion of host immune surveillance by hepatitis C virus: potential roles in viral persistence. [Arch Immunol Ther Exp (Warsz)....]
Review Evasion of host immune surveillance by hepatitis C virus: potential roles in viral persistence.
Moorman JP, Joo M, Hahn YS. Arch Immunol Ther Exp (Warsz). 2001; 49(3):189-94.
High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection. [J Immunol. 2008]
High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection.
Rutebemberwa A, Ray SC, Astemborski J, Levine J, Liu L, Dowd KA, Clute S, Wang C, Korman A, Sette A, et al. J Immunol. 2008 Dec 15; 181(12):8215-25.
Review The molecular basis of HCV-mediated immune dysregulation. [Clin Immunol. 2004]
Review The molecular basis of HCV-mediated immune dysregulation.
Eisen-Vandervelde AL, Yao ZQ, Hahn YS. Clin Immunol. 2004 Apr; 111(1):16-21.
Review Hepatitis C virus--T-cell responses and viral escape mutations. [Eur J Immunol. 2012]
Review Hepatitis C virus--T-cell responses and viral escape mutations.
Petrovic D, Dempsey E, Doherty DG, Kelleher D, Long A. Eur J Immunol. 2012 Jan; 42(1):17-26. Epub 2011 Nov 28.
Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus persistence. [J Immunol. 1999]
Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus persistence.
Large MK, Kittlesen DJ, Hahn YS. J Immunol. 1999 Jan 15; 162(2):931-8.

See reviews... See all...

Cited by 13 PubMed Central articles

Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species. [Hepatology. 2012]
Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species.
Tacke RS, Lee HC, Goh C, Courtney J, Polyak SJ, Rosen HR, Hahn YS. Hepatology. 2012 Feb; 55(2):343-53.
Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway. [J Biol Chem. 2011]
Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway.
Tacke RS, Tosello-Trampont A, Nguyen V, Mullins DW, Hahn YS. J Biol Chem. 2011 Mar 25; 286(12):10847-55. Epub 2011 Jan 31.
Review Immune defence, parasite evasion strategies and their relevance for 'macroscopic phenomena' such as virulence. [Philos Trans R Soc Lond B Biol...]
Review Immune defence, parasite evasion strategies and their relevance for 'macroscopic phenomena' such as virulence.
Schmid-Hempel P. Philos Trans R Soc Lond B Biol Sci. 2009 Jan 12; 364(1513):85-98.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Subversion of immune responses by hepatitis C virus: immunomodulatory strategies...
Subversion of immune responses by hepatitis C virus: immunomodulatory strategies beyond evasion?
Curr Opin Immunol. 2003 Aug ;15(4):443-9.

PubMed
The myogenic response in isolated rat cerebrovascular arteries: vessel model.
The myogenic response in isolated rat cerebrovascular arteries: vessel model.
Med Eng Phys. 2003 Oct ;25(8):711-7.

PubMed
Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein ty...
Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells.
Free Radic Biol Med. 2003 Aug 15 ;35(4):381-96.

PubMed
The effect of natural clinoptilolite on the serotonergic receptors in the brain ...
The effect of natural clinoptilolite on the serotonergic receptors in the brain of mice with mammary carcinoma.
Life Sci. 2003 Sep 5 ;73(16):2059-69.

PubMed
Are seasonalities in suicide dependent on suicide methods? A reappraisal.
Are seasonalities in suicide dependent on suicide methods? A reappraisal.
Soc Sci Med. 2003 Oct ;57(7):1173-81.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Subversion of immune responses by hepatitis C virus: immunomodulatory strategies beyond evasion?

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 13 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information