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Trends Neurosci. 2003 Aug;26(8):404-6.

Potential roles of insulin and IGF-1 in Alzheimer's disease.

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  • 1Nicox Research Institute, Via Ariosto 21, 20091 Bresso, Milan, Italy.


Aging is characterized by a significant decline of metabolic and hormonal functions, which often facilitates the onset of severe age-associated pathologies. One outstanding example of this is the reported association of deranged signaling by insulin and insulin-like-growth-factor 1 (IGF-1) with Alzheimer's disease (AD). Recent compelling biological data reveal effects of insulin and IGF-1 on molecular and cellular mechanisms underlying the pathology of AD. This review discusses available biological data that highlight the therapeutic potential of the insulin-IGF-1 signaling pathway in AD.

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