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A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis.

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  • 1Department of Medicine, Mayo Clinic and Foundation, 911A Guggenheim Building, 200 First Street S.W., Rochester, MN 55905, USA. rkumar@mayo.edu

Abstract

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.

PMID:
12899517
PMCID:
PMC2903742
[PubMed - indexed for MEDLINE]
Free PMC Article
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