Nat Rev Genet. 2003 Aug;4(8):587-97.

Haplotype blocks and linkage disequilibrium in the human genome.

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Department of Human Genetics, The University of Chicago, 920 East 58th Street, CLSC 507, Chicago, Illinois 60637, USA. jwall@genetics.bsd.uchicago.edu

Abstract

There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans and other species. Characterizing LD is of central importance for gene-mapping studies and can provide insights into the biology of recombination and human demographic history. Here, we review recent developments in this field, including the recently proposed 'haplotype-block' model of LD. We describe some of the recent data in detail and compare the observed patterns to those seen in simulations.

PMID:: 12897771; [PubMed - indexed for MEDLINE]

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