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Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9873-7. Epub 2003 Jul 31.

A SNARE required for retrograde transport to the endoplasmic reticulum.

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  • 1Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Parkville 3010, Australia.


SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are central components of the machinery mediating membrane fusion in all eukaryotic cells. Sequence analysis of the yeast genome revealed a previously uncharacterized SNARE, SNARE-like tail-anchored protein 1 (Slt1). Slt1 is an essential protein localized in the endoplasmic reticulum (ER). It forms a SNARE complex with Sec22 and the ER syntaxin Ufe1. Down-regulation of Slt1 levels leads to improper secretion of proteins normally resident in the ER. We suggest that Slt1 is a component of the SNAREpin required for retrograde traffic to the ER. Based on the previously reported association with Ufe1 and Sec22, Sec20 likely contributes the fourth SNARE to the SNAREpin.

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