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J Am Vet Med Assoc. 1992 Nov 15;201(10):1580-3.

Phenobarbital-responsive episodic dyscontrol (rage) in dogs.

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  • 1Department of Surgery, Tufts University School of Veterinary Medicine, North Grafton, MA 01536.


Episodic dyscontrol (rage) was diagnosed from the clinical history, electroencephalographic findings, and response to oral treatment with phenobarbital in 3 dogs. Clinical features included a mood change heralding aggressive incidents, explosive aggression directed at people or objects, and a postaggressive phase characterized by lethargy and lack of responsiveness. Abnormal electroencephalographic findings included spike activity in the temporal recordings. All 3 dogs responded well to anticonvulsant medication with phenobarbital.

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