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Urology. 2003 Aug;62(2):351.

Management of metastatic malignant melanoma of the bladder.

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  • 1Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, USA.


Recombinant interleukin-2 (IL-2) has demonstrated antitumor activity and durable clinical responses in patients with metastatic melanoma. Careful screening and selection of appropriate patients has improved the safety profile of IL-2 administration. Gross hematuria would ordinarily preclude the safe delivery of IL-2. We report a case of metastatic melanoma to the bladder presenting with hematuria. A complete resection was performed and subsequently allowed the administration of high-dose, bolus IL-2. The combination of resection and IL-2 therapy resulted in a partial response maintained for more than 18 months. Symptomatic bladder melanoma should be aggressively treated to allow for systemic immunotherapy, which can provide durable responses.

[PubMed - indexed for MEDLINE]
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