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Biol Psychiatry. 2003 Aug 1;54(3):241-7.

Depression, mortality, and medical morbidity in patients with coronary heart disease.

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  • 1Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63108, USA.


There is substantial evidence that depression is a risk factor for cardiac morbidity and mortality, both for patients without clinical evidence of coronary heart disease at index examination and for patients with established coronary disease. The relationship is most apparent for patients with a recent acute myocardial infarction. Many questions about the impact of depression on heart disease remain unresolved.

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