Your browser version may not work well with NCBI's Web applications. More information
here...
-
Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo.
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA.
A solvent, 1,4-butanediol, is also abused as a recreational drug. In mammals, 1,4-butanediol is metabolized into gamma-hydroxybutyric acid (GHB), which stimulates metabotropic gamma-aminobutyric acid (GABA) GABAB and putative GHB receptors. Here we show that in vivo injection of 1,4-butanediol into adult Drosophila leads to GHB synthesis (GHB was detectable 5 min after 1,4-butanediol injection and increased dramatically 1-2 h later). This synthesis of GHB was accompanied by an impairment of locomotor activity that was mimicked by a direct injection of GHB into flies. We propose Drosophila as a model to study the molecular actions of 1,4-butanediol and GHB.
PMID: 12892832 [PubMed - indexed for MEDLINE]
-
Related Articles
-
Related Reviews
-
Patient Drug Information
-
Penicillin G Potassium or Sodium Injection (Pfizerpen®)
Your doctor has ordered penicillin, an antibiotic, to help treat your infection. The drug will be either injected into a large muscle (such as your buttock or hip) or added to an intravenous fluid that will drip through ...
-
Sodium Oxybate (Xyrem®)
Sodium oxybate is used to prevent attacks of cataplexy (episodes of muscle weakness that begin suddenly and last for a short time) in patients who have narcolepsy (a sleep disorder that may cause extreme sleepiness, sudd...