Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 2003 Aug;15(4):438-45.

Retrograde traffic in the biosynthetic-secretory route: pathways and machinery.

Author information

  • 1Department of Anatomy and Cell Biology, University of Bergen, Jonas Lies vei 91, N-5009, Bergen, Norway.

Abstract

In the secretory pathway, the forward (anterograde) membrane flow is compensated by retrograde transport of proteins and lipids. Membrane recycling is required for the maintenance of organelle homeostasis and the re-use of components of the transport machineries for the generation of new transport intermediates. However, the molecular mechanisms and other cellular functions of retrograde traffic are still poorly understood. In recent years, a multitude of protein factors that function in the secretory pathway have been discovered, most of them originally suggested to play a role in forward trafficking. However, in many cases subsequent studies have revealed that these proteins participate (also) in retrograde traffic. It is likely that this shift will continue, reflecting the fact that the two pathways are intimately connected.

PMID:
12892784
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk