Br J Cancer. 2003 Aug 4;89(3):455-6.

Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin.

Gonzalez MA, Biswas S, Clifton L, Corrie PG.

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Oncology Centre (Box 193), Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.

Abstract

A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin. Overall objective response rate was 53% and tolerability was excellent.

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Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin.

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