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J Antimicrob Chemother. 2003 Sep;52(3):522-3. Epub 2003 Jul 29.

Mastic gum has no effect on Helicobacter pylori load in vivo.

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  • 1Division of Gastroenterology, University Hospital, Nottingham, NG7 2UH, UK.

Abstract

OBJECTIVE:

To determine whether mastic gum suppresses or eradicates Helicobacter pylori infection in humans.

PATIENTS AND METHODS:

Nine patients with H. pylori infection, and without gastroduodenal ulceration, were recruited from day-case endoscopy lists and treated with mastic 1 g four times daily for 14 days. [13C]Urea breath tests (UBTs) were carried out immediately before, on day 15 and 5 weeks after treatment with mastic.

RESULTS:

Mastic had no effect on H. pylori status in any of the eight completed patients; all remained H. pylori positive by UBT with no change in delta scores [pre-treatment mean +/- s.e.m. 19.1 +/- 3.7, day 15 (post-treatment) 18.7 +/- 3.8, P = 0.8, paired t-test].

CONCLUSION:

Despite reported anti-H. pylori action in vitro, this preliminary study shows that mastic has no effect on H. pylori in humans.

PMID:
12888582
[PubMed - indexed for MEDLINE]
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