Cilia are at the heart of vertebrate left-right as...[Curr Opin Genet Dev. 2003]

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1: Curr Opin Genet Dev. 2003 Aug;13(4):385-92. Links

Cilia are at the heart of vertebrate left-right asymmetry.

McGrath J, Brueckner M.

Department of Comparative Medicine and Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Handed asymmetry of the shape and position of the internal organs is found in all vertebrates, and is essential for normal cardiac development. Recent genetic and embryological experiments in mouse embryos have demonstrated that left-right asymmetry is established by directional flow of extraembryonic fluid surrounding the node, which is driven by motile monocilia.

PMID: 12888012 [PubMed - indexed for MEDLINE]

Cilia propel the embryo in the right direction. [Am J Med Genet. 2001]
Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. [Development. 2005]
Do we know anything about how left-right asymmetry is first established in the vertebrate embryo? [J Mol Histol. 2005]
Fluid-dynamical basis of the embryonic development of left-right asymmetry in vertebrates. [Proc Natl Acad Sci U S A. 2004]
[Mechanisms for establishment of vertebrate left-right asymmetry] [Tanpakushitsu Kakusan Koso. 2005]
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Cilia are at the heart of vertebrate left-right asymmetry.

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