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Cancer Genet Cytogenet. 2003 Aug;145(1):78-81.

Mosaic trisomy 2 in myelodysplastic syndromes and acute myeloblastic leukemias.

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  • 1Department of Cytogenetics, The Rayne Institute, King's College Hospital, London, UK.


We present a short report here of two more patients with trisomy 2 as the sole chromosomal abnormality in a hematologic malignancy. Although trisomy 2 is a recognized abnormality in neoplasms, particularly hepatoblastomas, to the best of our knowledge only three other cases have been reported with trisomy 2, in patients with a hematologic malignancy. The two cases presented here of myelodysplastic syndrome transforming to acute myeloblastic leukemia and chronic myelomonocytic leukemia showed trisomy 2 as the sole abnormality.

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