Cyclodextrin-assisted capillary electrophoresis for determination of the cyclic nitramine explosives RDX, HMX and CL-20 comparison with high-performance liquid chromatography

J Chromatogr A. 2003 May 30;999(1-2):17-22. doi: 10.1016/s0021-9673(03)00389-3.

Abstract

A sulfobutyl ether-beta-cyclodextrin-assisted electrokinetic chromatographic method was developed to rapidly resolve and detect the cyclic nitramine explosives 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaaza-isowurtzitane (CL-20), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and their related degradation intermediates in environmental samples. Development of the electrophoretic method required the measurement of the aqueous solubility of CL-20 which was determined to be 3.59 +/- 0.74 mg/l at 25 degrees C (95% confidence interval, n=3). The performance of the method was then compared to results obtained from existing high-performance liquid chromatography methods including US Environmental Protection Agency method 8330.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aza Compounds / analysis*
  • Azocines / analysis*
  • Chromatography, High Pressure Liquid / methods*
  • Electrophoresis, Capillary / methods*
  • Heterocyclic Compounds / analysis*
  • Heterocyclic Compounds, 1-Ring / analysis*
  • Sensitivity and Specificity
  • Spectrophotometry, Ultraviolet
  • Triazines / analysis*

Substances

  • 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaaza-isowurtzitane
  • Aza Compounds
  • Azocines
  • Heterocyclic Compounds
  • Heterocyclic Compounds, 1-Ring
  • Triazines
  • octogen
  • cyclonite