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J Pediatr Gastroenterol Nutr. 2003 Aug;37(2):150-4.

Dermatologic manifestations of Crohn disease in children: response to infliximab.

Author information

  • 1Division of Pediatric Gastroenterology and Nutrition, Children's Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA. skuga@mcw.edu

Abstract

Dermatologic extraintestinal manifestations of Crohn disease may be refractory to treatment with corticosteroids and immunomodulators. The authors describe four children with Crohn disease with dermatologic manifestations: pyoderma gangrenosum, orofacial involvement, erythema nodosum, and idiopathic lymphedema. These dermatologic conditions were unresponsive to conventional therapy but had rapid and sustained response to the anti-TNF-alpha antibody infliximab. No adverse reactions occurred. Infliximab should be considered for treating the extraintestinal dermatologic manifestations of Crohn disease in children.

PMID:
12883301
[PubMed - indexed for MEDLINE]
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