J Nat Prod. 2003 Jul;66(7):922-7.

Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins.

Yoshikawa M, Morikawa T, Kashima Y, Ninomiya K, Matsuda H.

Source

Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. shoyaku@mb.kyoto-phu.ac.jp

Abstract

The saponin fraction from the flower buds of Panax notoginseng exhibited protective effect on liver injury induced by d-galactosamine and lipopolysaccharide. From the saponin fraction with hepatoprotective effect, five new dammarane-type triterpene saponins, notoginsenosides-O (1), -P (2), -Q (3), -S (4), and -T (5), were isolated together with nine known protopanaxadiol oligoglycosides. The structures of the new saponins were elucidated on the basis of chemical and physicochemical evidence. The principal dammarane-type triterpene saponins from the roots and flower buds of Panax notoginseng were found to show potent hepatoprotective effects.

PMID:: 12880307; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Related citations

Bioactive saponins and glycosides. VIII. Notoginseng (1): new dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D, from the dried root of Panax notoginseng (Burk.) F.H. Chen. [Chem Pharm Bull (Tokyo). 1997]
Bioactive saponins and glycosides. VIII. Notoginseng (1): new dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D, from the dried root of Panax notoginseng (Burk.) F.H. Chen.
Yoshikawa M, Murakami T, Ueno T, Yashiro K, Hirokawa N, Murakami N, Yamahara J, Matsuda H, Saijoh R, Tanaka O. Chem Pharm Bull (Tokyo). 1997 Jun; 45(6):1039-45.
Bioactive saponins and glycosides. XI. Structures of new dammarane-type triterpene oligoglycosides, quinquenosides I, II, III, IV, and V, from American ginseng, the roots of Panax quinquefolium L. [Chem Pharm Bull (Tokyo). 1998]
Bioactive saponins and glycosides. XI. Structures of new dammarane-type triterpene oligoglycosides, quinquenosides I, II, III, IV, and V, from American ginseng, the roots of Panax quinquefolium L.
Yoshikawa M, Murakami T, Yashiro K, Yamahara J, Matsuda H, Saijoh R, Tanaka O. Chem Pharm Bull (Tokyo). 1998 Apr; 46(4):647-54.
Dammarane-type triterpene saponins from the flowers of Panax notoginseng. [Molecules. 2009]
Dammarane-type triterpene saponins from the flowers of Panax notoginseng.
Wang JR, Yamasaki Y, Tanaka T, Kouno I, Jiang ZH. Molecules. 2009 Jun 10; 14(6):2087-94. Epub 2009 Jun 10.
Review New saponins from Vietnamese ginseng: highlights on biogenesis of dammarane triterpenoids. [Adv Exp Med Biol. 1996]
Review New saponins from Vietnamese ginseng: highlights on biogenesis of dammarane triterpenoids.
Duc NM, Kasai R, Ohtani K, Ito A, Yamasaki K, Nguyen TN, Tanaka O. Adv Exp Med Biol. 1996; 404:129-49.
Review Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. [J Korean Med Sci. 2001]
Review Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds.
Shibata S. J Korean Med Sci. 2001 Dec; 16 Suppl:S28-37.

See reviews... See all...

Cited by 1 PubMed Central article

Review Isolation and analysis of ginseng: advances and challenges. [Nat Prod Rep. 2011]
Review Isolation and analysis of ginseng: advances and challenges.
Qi LW, Wang CZ, Yuan CS. Nat Prod Rep. 2011 Mar; 28(3):467-95. Epub 2011 Jan 24.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioAssay
PubChem BioAssay experiments on the biological activities of small molecules that cite the current articles. The depositors of BioAssay data provide these references.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Structures of new dammarane-type Triterpene Saponins from the flower buds of Pan...
Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins.
J Nat Prod. 2003 Jul ;66(7):922-7.

PubMed
Hypoxia induces expression and activation of AMPK in rat dental pulp cells.
Hypoxia induces expression and activation of AMPK in rat dental pulp cells.
J Dent Res. 2007 Sep ;86(9):903-7.

PubMed
Stroke treatment economic model (STEM): predicting long-term costs from function...
Stroke treatment economic model (STEM): predicting long-term costs from functional status.
Stroke. 1999 Dec ;30(12):2574-9.

PubMed
Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of ...
Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis.
Mol Biol Cell. 2005 Oct ;16(10):4841-51. Epub 2005 Jul 29 .

PubMed
Differential effects of erythropoietin on neural and cognitive measures of execu...
Differential effects of erythropoietin on neural and cognitive measures of executive function 3 and 7 days post-administration.
Exp Brain Res. 2008 Jan ;184(3):313-21. Epub 2007 Sep 8 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information