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Anal Bioanal Chem. 2003 Oct;377(3):528-39. Epub 2003 Jul 19.

Present and future of surface plasmon resonance biosensors.

Author information

  • Institute of Radio Engineering and Electronics, Academy of Sciences of the Czech Republic, Chabersk√° 57, Prague, Czech Republic. homola@ure.cas.cz


Surface plasmon resonance (SPR) biosensors are optical sensors exploiting special electromagnetic waves-surface plasmon-polaritons-to probe interactions between an analyte in solution and a biomolecular recognition element immobilized on the SPR sensor surface. Major application areas include detection of biological analytes and analysis of biomolecular interactions where SPR biosensors provide benefits of label-free real-time analytical technology. This paper reviews fundamentals of SPR affinity biosensors and discusses recent advances in development and applications of SPR biosensors.

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