Format

Send to:

Choose Destination
See comment in PubMed Commons below
Eur Urol. 2003 Aug;44(2):226-32.

Correlation between symptom graduation, tumor characteristics and survival in renal cell carcinoma.

Author information

  • 1Service d'Urologie, CHU Pontchaillou, rue Henri Le Guilloux, 35033 Rennes, France. jean-jacques.patard@chu-rennes.fr

Abstract

OBJECTIVES:

To compare renal tumors with respect to initial clinical presentation and assess the prognostic value of a symptom based classification.

MATERIAL AND METHODS:

Based on symptoms at diagnosis, 388 renal tumors were stratified into three groups: (1) asymptomatic tumors; (2) tumors with local symptoms (3) tumors with systemic symptoms. The three groups were compared for usual clinical and pathological variables using chi(2)-tests and Anova regression, for qualitative and quantitative variables, respectively. Survival assessment was made with univariate and multivariate analysis using the Kaplan-Meier method and Cox regression analysis.

RESULTS:

The three defined groups were significantly different for all analysed variables except for age, sex ratio and pathological subtype. In univariate analysis: ECOG performance status, symptom classification, tumour size, TNM stage and grade, adrenal, perinephric fat or vein invasion were significant prognostic factors (p<0.001). In multivariate analysis, symptom classification, TNM stage, Fuhrman grade and perinephric fat invasion remained independent prognostic factors (p<0.001).

CONCLUSION:

The proposed classification merits further validation through multi-institutional studies before integrating it in further prognosis algorithms.

PMID:
12875943
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk