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Infect Immun. 2003 Aug;71(8):4815-7.

Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice.

Author information

  • 1Biology Department, University of Utah, Salt Lake City, Utah 84112, USA. Erin.McClelland@m.cc.utah.edu

Abstract

To evaluate the role of major histocompatibility complex (MHC) genes in the resistance to Cryptococcus neoformans, we conducted infection experiments in MHC-congenic strains of mice. Significant MHC-dependent susceptibility differences were found among homozygotes and heterozygotes. This study is the first experimental demonstration of MHC-dependent susceptibility to C. neoformans infections in mice and indicates that MHC genes can be important in host resistance.

PMID:
12874366
[PubMed - indexed for MEDLINE]
PMCID:
PMC166009
Free PMC Article
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