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Bioorg Med Chem Lett. 2003 Aug 18;13(16):2637-9.

4-Phenyl-4H-pyrans as IK(Ca) channel blockers.

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  • 1Institute of Medicinal Chemistry, Pharma Research Center, Bayer AG, D-42096, Wuppertal, Germany. klaus.urbahns.ku1@bayer.co.jp

Abstract

4-Phenyl-4H-pyrans have been identified as potent and specific IK(Ca) channel blockers. Their synthesis and structure-activity relationships are described. A selected derivative, rac-11, reduces the infarct volume in a rat subdural hematoma model of traumatic brain injury after iv administration.

PMID:
12873483
[PubMed - indexed for MEDLINE]

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