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Muscle Nerve. 2003 Aug;28(2):133-43.

Lyme disease and the peripheral nervous system.

Author information

  • 1Department of Neurology, North Shore University Hospital, 300 Community Drive, Manhasset, New York 11030, USA. halperin@nshs.edu

Abstract

Lyme disease, the multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi, causes a broad variety of peripheral nerve disorders, including single or multiple cranial neuropathies, painful radiculopathies, and diffuse polyneuropathies. Virtually all appear to be varying manifestations of a mononeuropathy multiplex. Diagnosis requires that the patient should have had possible exposure to the only known vectors, Ixodes ticks, and also have either other pathognomonic clinical manifestations or laboratory evidence of exposure. Treatment with antimicrobial regimens is highly effective. The mechanism underlying these neuropathies remains unclear, although interactions between anti-Borrelia antibodies and several peripheral nerve constituent molecules raise intriguing possibilities.

PMID:
12872317
[PubMed - indexed for MEDLINE]
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