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J Thromb Haemost. 2003 Feb;1(2):231-8.

Fibrinogen gamma chain functions.

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  • 1The Blood Research Institute of the Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, Wisconsin 53201-2178, USA.


This review covers the functional features of the fibrinogen gamma chains including their participation in fibrin polymerization and cross-linking, their role in the initiation of fibrinolysis, their binding and regulation of factor XIII activity, their interactions with platelets and other cells, and their role in mediating thrombin binding to fibrin, a thrombin inhibitory function termed 'antithrombin I'.

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