Abstract
Extensive evidence supports oxidative stress (OS) via endogenous and exogenous agents as an important factor in induction of autoimmunity. OS arises from the immune system and other endogenous sources. The literature contains support for OS involvement of various drugs and other exogenous substances that produce the condition. Studies reveal prevention or amelioration by antioxidants.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Antioxidants / pharmacology
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Autoimmune Diseases / chemically induced
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Autoimmune Diseases / drug therapy
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Autoimmune Diseases / metabolism*
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Humans
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Lupus Erythematosus, Systemic / chemically induced
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Lupus Erythematosus, Systemic / drug therapy
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Lupus Erythematosus, Systemic / metabolism*
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Oxidants / chemistry
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Oxidants / metabolism*
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Oxidative Stress / drug effects
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Reactive Oxygen Species / metabolism
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Xenobiotics / administration & dosage
Substances
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Antioxidants
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Oxidants
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Reactive Oxygen Species
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Xenobiotics