AIDS. 2003 Apr;17 Suppl 1:S21-8.

Immunopathogenesis of HIV-related heart muscle disease: current perspectives.

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Perth Royal Infirmary, Perth, UK.

Abstract

As more effective antiretroviral therapies improve survival times, growing numbers of HIV-positive patients are at risk of developing end-organ damage or neoplasia. Heart muscle disease is the most important cardiovascular manifestation of HIV infection and seems set to become increasingly prevalent. This may take the form of either a dilated cardiomyopathy or isolated left or right ventricular dysfunction, is associated with a poor prognosis, and results in symptomatic heart failure in up to 5% of HIV patients. The precise cause of HIV-associated cardiomyopathy remains unclear but is undoubtedly complex, and most probably multifactorial. This report examines our current understanding of the immunopathogenesis of HIV-associated cardiomyopathy.

PMID:: 12870527; [PubMed - indexed for MEDLINE]

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