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News Physiol Sci. 2003 Aug;18:147-50.

Cell adhesion molecules: key players in memory consolidation?

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  • 1Division of Neuroanatomy and Behavior, Institute of Anatomy, University of Zurich, CH-8057 Zurich, Switzerland.


Experimental evidence implies that L1 and neural cell adhesion molecule (NCAM) are involved in long-term memory formation. Changes in their expression and glycosylation appear to modify the synaptic strength underlying memory consolidation. Interference with L1 and NCAM function in a variety of learning tasks in different species severely attenuates memory consolidation, indicating their involvement in an evolutionary conserved mechanism of neural plasticity.

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