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Trop Med Int Health. 2003 Aug;8(8):733-9.

Visceral leishmaniasis and HIV in Tigray, Ethiopia.

Author information

  • 1Department of Public Health and Epidemiology, UCD, National University of Ireland, Dublin, Ireland. suzanne.lyons@ucd.ie

Abstract

OBJECTIVES:

To identify characteristics that increased the risk of mortality in Ethiopian visceral leishmaniasis patients in a treatment programme managed by Médecins sans Frontières, in Tigray, Northern Ethiopia.

METHODS:

Retrospective review of a cohort of 791 patients treated for visceral leishmaniasis.

RESULTS:

The cohort displayed all the classical signs and symptoms of the disease. The case fatality rate was 18.5% (146) (95% CI: 15.8-21.3%). Logistic regression showed that individuals who experienced at least one episode of vomiting or haemorrhage were more likely to die than those who did not. A subcohort of individuals who tested human immunodeficiency virus (HIV)-positive were more than four times more likely to die than those who tested HIV-negative (OR 4.5, 95% CI: 1.8-11.4).

CONCLUSION:

This study identifies characteristics associated with death in this population and highlights the devastating effect of co-infection with visceral leishmaniasis and HIV in the African context.

PMID:
12869095
[PubMed - indexed for MEDLINE]
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