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Genet Med. 2003 Jul-Aug;5(4):304-10.

HFE genotype and transferrin saturation in the United States.

Author information

  • 1Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA.

Abstract

PURPOSE:

Examine the penetrance (defined by high transferrin saturation [TS]) of C282Y and H63D in the U.S. population.

METHODS:

5171 participants from the Third National Health and Nutrition Examination Survey, 1992 to 1994.

RESULTS:

77.1% (95% confidence interval [CI], 2.3, 95.1) of men and 51.9% (95% CI, 0, 84.2) of women with C282Y homozygosity had high TS. The associations of H63D homozygosity with high TS were stronger in people aged 50 years or older than in younger persons. Among Mexican-Americans, simple H63D heterozygosity was associated with high TS.

CONCLUSIONS:

The associations between HFE genotype and high TS may vary by sex, age, and ethnic group.

PMID:
12865759
[PubMed - indexed for MEDLINE]
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