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CNS Spectr. 2003 Jun;8(6):446-9.

The link between glutamate and migraine.

Author information

  • 1Department of Neurology, Finch University of Health Sciences/The Chicago Medical School, Chicago, Illinois 60064-3095, USA. ramadan@finchcms.edu

Abstract

Migraine pain-relay centers, including the trigeminal ganglion, trigeminal nucleus caudalis, and thalamus, contain glutamate-positive neurons, and glutamate activates the trigeminal nucleus caudalis. Glutamate is implicated in cortical spreading depression, trigeminovascular activation, and central sensitization. Glutamate receptor-subtype antagonists are effective in preclinical models of migraine, and in the clinic. These preclinical and clinical observations argue for a strong link between migraine and the glutamatergic system, a link that is important to further characterize in an effort to better understand migraine mechanisms and deliver effective therapies.

PMID:
12858134
[PubMed - indexed for MEDLINE]
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