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J Palliat Med. 2003 Apr;6(2):251-5.

Olanzapine for intractable nausea in palliative care patients.

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  • 1Department of Family Medicine, The University of Tennessee Health Sciences Center, Memphis, Tennessee 38104, USA.


Nausea is a common problem among palliative care patients, which is often undertreated. Olanzapine, an atypical antipsychotic, possesses a unique neurotransmitter binding profile that is similar to methotrimeprazine, an anti-emetic widely used in Europe for recalcitrant nausea. We report a case series of six patients who suffered nausea which was resistant to initial treatment with traditional antiemetics; each patient exhibited marked improvement when treated with olanzapine.

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