Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann N Y Acad Sci. 2003 Jun;994:111-7.

Expression, desensitization, and internalization of the ACTH receptor (MC2R).

Author information

  • 1Department of Endocrinology, Queen Mary University of London, London EC1A 7BE, United Kingdom. a.j.clark@qmul.ac.uk

Abstract

Research into the functions and mechanisms of action of the melanocortin 2 receptor (MC2R) has been severely hampered by difficulties in expressing this gene in heterologous cells. This probably arises because of the need for a cofactor for cell surface expression. Using either the Y1 cell line that expresses endogenous MC2R or the Y6 cell line that expresses this putative expression factor, we have explored the mechanisms of desensitization and internalization after agonist stimulation. Protein kinase A dependence of desensitization has been demonstrated, although internalization is apparently independent of this kinase and dependent on a G protein receptor kinase. Possible underlying reasons for this paradox are discussed.

PMID:
12851305
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk