Send to:

Choose Destination
See comment in PubMed Commons below
Drug Discov Today. 2003 Jul 1;8(13):594-602.

Chemical substructures in drug discovery.

Author information

  • 1Serono Pharmaceutical Research Institute, 14, ch. des Aulx, 1228-Plan-les-Ouates, Geneva, Switzerland.


The widespread use of HTS and combinatorial chemistry techniques has led to the generation of large amounts of pharmacological data, which, in turn, has catalyzed the development of computational methods designed to reduce the time and cost in identifying molecules suitable for pharmaceutical development. This review focuses on the use of substructure-based in silico techniques for lead discovery, an effective and increasingly popular approach for augmenting the chance of selecting drug-like compounds for preclinical and clinical development.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk