Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Autoimmun Rev. 2003 Jun;2(4):204-10.

Proinsulin-a pathogenic autoantigen in type 1 diabetes.

Author information

  • 1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3050 Parkville, Australia.

Abstract

Type 1 diabetes (T1D) is an autoimmune disease characterised by immunity to pancreatic beta-cell autoantigens, associated with beta-cell destruction leading to insulin deficiency and hyperglycaemia. The rigorous definition of an autoimmune disease requires evidence that an autoantigen elicits pathological immune responses. Using criteria for the pathogenicity of an autoantigen, we examine the evidence for proinsulin as an autoantigen in T1D. We conclude that proinsulin satisfies these criteria. As a corollary, proinsulin is a potential immunotherapeutic tool for the prevention of T1D.

PMID:
12848947
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk