Dig Liver Dis. 2003 May;35 Suppl 2:S61-9.

Nitric oxide and portal hypertension: a nitric oxide-releasing derivative of ursodeoxycholic acid that selectively releases nitric oxide in the liver.

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Gastrointestinal and Liver Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy. fiorucci@unipg.it

Abstract

Portal hypertension, a common consequence of chronic liver diseases, is directly responsible for most complications of cirrhosis. In liver microcirculation, nitric oxide is considered a major fine tuner of vascular tone by counterbalancing vasoconstrictors (sympathetic nervous activity, the renin-angiotensin system, and endothelin-1) in normal and cirrhotic livers. The deficiency of endothelial nitric oxide release is a key factor in the hemodynamic abnormalities associated with the dynamic component of portal hypertension. Conventional nitric oxide donors release nitric oxide into the blood stream, causing systemic hypotension and progression of vasodilatory syndrome in cirrhotic patients. NCX1000 is a nitric oxide-releasing derivative of ursodeoxycholic acid-derived compounds, being capable of selectively releasing nitric oxide into the liver circulation. Administration of NCX1000 to portal hypertensive rats decreases intrahepatic resistance providing a novel therapy for the treatment of portal hypertension.

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Review Treatment of portal hypertension with NCX-1000, a liver-specific NO donor. A review of its current status. [Cardiovasc Drug Rev. 2004]
Review Treatment of portal hypertension with NCX-1000, a liver-specific NO donor. A review of its current status.
Fiorucci S, Antonelli E, Tocchetti P, Morelli A. Cardiovasc Drug Rev. 2004 Summer; 22(2):135-46.
NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver. [J Hepatol. 2003]
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NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension. [Proc Natl Acad Sci U S A. 2001]
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Fiorucci S, Antonelli E, Morelli O, Mencarelli A, Casini A, Mello T, Palazzetti B, Tallet D, del Soldato P, Morelli A. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8897-902. Epub 2001 Jul 10.
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Cited by 1 PubMed Central article

NCX 1000 Alone or in Combination with Vitamin E Reverses Experimental Nonalcoholic Steatohepatitis in the Rat Similarly to UDCA. [Int J Hepatol. 2011]
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Haddad Y, Vallerand D, Brault A, Spénard J, Haddad PS. Int J Hepatol. 2011; 2011:136816. Epub 2011 Oct 16.

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Dig Liver Dis. 2003 May ;35 Suppl 2:S61-9.

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