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Epidemiology. 2003 Jul;14(4):429-36.

Risk factors for female infertility in an agricultural region.

Author information

  • 1Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA. greenlee.anne@mmrf.mfldclin.edu

Abstract

BACKGROUND:

Recent studies have suggested that agricultural occupations or exposure to pesticides may impair female fertility.

METHODS:

The Fertility Risk Factor Study retrospectively examined agricultural and residential exposures and the risk of female infertility. Cases and controls (N = 322 each) came from women who sought treatment at a large group medical clinic in Wisconsin. Women and their male partners provided information on health, occupational and lifestyle exposures in response to a telephone interview during 1997-2001.

RESULTS:

Mixing and applying herbicides 2 years before attempting conception was more common among infertile women (odds ratio [OR] = 27; 95% confidence interval [CI] = 1.9-380), as was the use of fungicides (OR = 3.3; CI = 0.8-13). Residing on a farm, ranch or in a rural area during this time period was protective of female fertility. Households supplied with central Wisconsin groundwater were at less risk for infertility than households using municipal sources (OR = 0.6; CI = 0.4-0.9). Behavioral risk factors included alcohol consumption (OR = 1.8; 1.2-2.5), smoking (1.6; 0.9-2.9), passive smoke exposure (1.8; 1.2-2.5), steady weight gain in adult life (3.5; 2.0-6.1), and having a male partner over the age of 40 (4.5; 1.2-16.3). Drinking 3 or more glasses of milk per day was protective of female fertility (0.3; 0.1-0.7).

CONCLUSION:

These results suggest that certain agricultural, residential and lifestyle choices may modify the risk of female infertility.

PMID:
12843768
[PubMed - indexed for MEDLINE]
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