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1: Rheum Dis Clin North Am. 2003 May;29(2):391-408.Links

Musculoskeletal involvement in scleroderma.

Pope JE.

Division of Rheumatology, Department of Medicine, The University of Western Ontario, Canada. janet.pope@sjhc.london.on.ca

Scleroderma can be accompanied by arthralgias, inflammatory arthritis, flexion contractures, nerve entrapment, myositis, or myopathy. Antibodies in scleroderma can occur in other connective tissue diseases; overlap syndromes between scleroderma and Sjogren's syndrome, lupus, and rheumatoid arthritis are reported. Many of the musculoskeletal symptoms in scleroderma are treated symptomatically; most treatments are not proven in randomized controlled trials in these patients. Musculoskeletal manifestations are a major cause of morbidity and disability in scleroderma.

PMID: 12841301 [PubMed - indexed for MEDLINE]