Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients.
Alizadeh M,
Babron MC,
Birebent B,
Matsuda F,
Quelvennec E,
Liblau R,
Cournu-Rebeix I,
Momigliano-Richiardi P,
Sequeiros J,
Yaouanq J,
Genin E,
Vasilescu A,
Bougerie H,
Trojano M,
Martins Silva B,
Maciel P,
Clerget-Darpoux F,
Clanet M,
Edan G,
Fontaine B,
Semana G.
Laboratoire Universitaire d'Immunologie (UPRES EA 1257, IFR 97) and Etablissement Français du Sang Bretagne, Faculté de Médecine, Rennes, France.
Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios. Ann Neurol 2003;54:119-122
PMID: 12838528 [PubMed - indexed for MEDLINE]