Display Settings:

Format

Send to:

Choose Destination
Br J Cancer. 2003 Jul 7;89(1):101-5.

Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis.

Author information

  • 1Unit of Field and Intervention Studies, International Agency for Research on Cancer, 150, cours Albert Thomas, 69008, Lyon, France. clifford@iarc.fr

Abstract

Particular types of human papillomavirus (HPV) infection may preferentially progress from high-grade squamous intraepithelial lesions (HSIL) to squamous cell carcinoma of the cervix (SCC). We performed a meta-analysis of published data to compare HPV type distribution in HSIL and SCC. HPV16, 18 and 45 were each more prevalent in SCC than HSIL, whereas the reverse was true for other oncogenic types including HPV31, 33, 52 and 58. These data suggest that HSILs infected with HPV16, 18 and 45 preferentially progress to SCC. This may have implications for follow-up protocols of future HPV-based cervical cancer screening programmes and for HPV vaccine trials.

PMID:
12838308
[PubMed - indexed for MEDLINE]
PMCID:
PMC2394204
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk