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Trends Cell Biol. 2003 Jul;13(7):340-3.

Centrosome size is controlled by centriolar SAS-4.

Author information

  • Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA. salisbury@mayo.edu


The centrosome consists of a pair of centrioles and a surrounding matrix of pericentriolar material that anchors microtubule nucleation sites and consequently determines the number and organization of microtubules in interphase and mitotic cells. Recent studies utilizing a functional genomics approach in the nematode worm Caenorhabditis elegans and sophisticated light and electron microscopy techniques provide new insight into how centrioles act as centrosomal organizers and use a centriolar structural element to dictate centrosome size by defining their capacity to recruit pericentriolar material.

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