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Leukemia. 2003 Jul;17(7):1205-10.

The adult hemopoietic stem cell plasticity debate: idols vs new paradigms.

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  • 1Roger Williams Medical Center, Center for Stem Cell Biology, Providence, Rhode Island 02908-4735, USA.


The debate surrounding adult stem cell plasticity derives from a confusion regarding definitions of important terms and the identification of key questions. After defining plasticity, lineage, differentiation and transdifferentiation, the authors put forth a framework for future dialogue as well as their perspective on the stem cell plasticity debate.

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