Nat Rev Cancer. 2003 Jul;3(7):517-25.

Curing metastatic cancer: lessons from testicular germ-cell tumours.

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The Prostate Cancer Research Centre, Institute of Urology, University College London, 3rd Floor, 67 Riding House Street, London W1W 7EJ, UK. j.masters@ucl.ac.uk

Abstract

Most metastatic cancers are fatal. More than 80% of patients with metastatic testicular germ-cell tumours (TGCTs), however, can be cured using cisplatin-based combination chemotherapy. Why are TGCTs more sensitive to chemotherapeutics than most other tumour types? Answers to this question could lead to new treatments for metastatic cancers.

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