Psychiatry Res. 1992 Nov;45(3):153-68.

Positron emission tomography with 18F-dopa: interpretation and biological correlates in nonhuman primates.

Doudet DJ, Aigner TG, McLellan CA, Cohen RM.

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Laboratory of Cerebral Metabolism, National Institute of Mental Health, NIH, Bethesda, MD 20892.

Abstract

Positron emission tomography (PET) was carried out, with 18F-DOPA as a ligand, in normal control monkeys and "parkinsonian" monkeys who had been treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The following approaches were used in data analysis: ratio of 18F accumulation in specific to nonspecific brain areas and 18F-DOPA influx constant obtained using either the actual plasma 18F-DOPA or the 18F activity in a nonspecific brain area as the input function. The results from these analyses were compared to one another and to biological parameters relevant to dopaminergic function. The striatum/cortex ratio and the rate constant calculated from plasma 18F-DOPA appeared to be the most sensitive analytic techniques.

PMID:: 1283014; [PubMed - indexed for MEDLINE]

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Positron emission tomography with 18F-dopa: interpretation and biological correlates in nonhuman primates.

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