Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA. james.markmann@uphs.upenn.edu
There is growing interest in more widespread application of isolated islet transplantation for the treatment of type 1 diabetes; however, the sequelae of long-term islet residence within the liver are unknown. We report herein a consequence of intraportal islet transplantation, specifically the development of periportal hepatic steatosis apparently induced by the local secretion of insulin within the liver.