Trends Biochem Sci. 2003 Jun;28(6):294-304.

The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.

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Cold Spring Harbor Laboratory, NY 11724, USA.

Abstract

When herpes simplex virus (HSV) infects human cells, it is able to enter two modes of infection: lytic and latent. A key activator of lytic infection is a virion protein called VP16, which, upon infection of a permissive cell, forms a transcriptional regulatory complex with two cellular proteins - the POU-domain transcription factor Oct-1 and the cell-proliferation factor HCF-1 - to activate transcription of the first set of expressed viral genes. This regulatory complex, called the VP16-induced complex, reveals mechanisms of combinatorial control of transcription. The activities of Oct-1 and HCF-1 - two important regulators of cellular gene expression and proliferation - illuminate strategies by which HSV might coexist with its host.

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DNA recognition by the herpes simplex virus transactivator VP16: a novel DNA-binding structure. [Mol Cell Biol. 2001]
DNA recognition by the herpes simplex virus transactivator VP16: a novel DNA-binding structure.
Babb R, Huang CC, Aufiero DJ, Herr W. Mol Cell Biol. 2001 Jul; 21(14):4700-12.
The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF. [J Virol. 1998]
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Review The herpes simplex virus VP16-induced complex: mechanisms of combinatorial transcriptional regulation. [Cold Spring Harb Symp Quant Bi...]
Review The herpes simplex virus VP16-induced complex: mechanisms of combinatorial transcriptional regulation.
Herr W. Cold Spring Harb Symp Quant Biol. 1998; 63:599-607.
Review Herpes simplex virus Vmw65-octamer binding protein interaction: a paradigm for combinatorial control of transcription. [Virology. 1989]
Review Herpes simplex virus Vmw65-octamer binding protein interaction: a paradigm for combinatorial control of transcription.
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