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Nucleic Acids Res. 2003 Jul 1;31(13):3621-4.

MHCPred: A server for quantitative prediction of peptide-MHC binding.

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  • 1Edward Jenner Institute for Vaccine Research, High Street, Compton, Berkshire RG0 7NN, UK.

Abstract

Accurate T-cell epitope prediction is a principal objective of computational vaccinology. As a service to the immunology and vaccinology communities at large, we have implemented, as a server on the World Wide Web, a partial least squares-based multivariate statistical approach to the quantitative prediction of peptide binding to major histocom- patibility complexes (MHC), the key checkpoint on the antigen presentation pathway within adaptive cellular immunity. MHCPred implements robust statistical models for both Class I alleles (HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203, HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3301, HLA-A*6801, HLA-A*6802 and HLA-B*3501) and Class II alleles (HLA-DRB*0401, HLA-DRB*0401 and HLA-DRB*0701). MHCPred is available from the URL: http://www.jenner.ac.uk/MHCPred.

PMID:
12824380
[PubMed - indexed for MEDLINE]
PMCID:
PMC168917
Free PMC Article
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