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Nucleic Acids Res. 2003 Jul 1;31(13):3381-5.

SWISS-MODEL: An automated protein homology-modeling server.

Author information

  • 1Biozentrum der Universit├Ąt Basel, Klingelbergstr. 50-70, CH 4056 Basel, Switzerland. torsten.schwede@unibas.ch

Abstract

SWISS-MODEL (http://swissmodel.expasy.org) is a server for automated comparative modeling of three-dimensional (3D) protein structures. It pioneered the field of automated modeling starting in 1993 and is the most widely-used free web-based automated modeling facility today. In 2002 the server computed 120 000 user requests for 3D protein models. SWISS-MODEL provides several levels of user interaction through its World Wide Web interface: in the 'first approach mode' only an amino acid sequence of a protein is submitted to build a 3D model. Template selection, alignment and model building are done completely automated by the server. In the 'alignment mode', the modeling process is based on a user-defined target-template alignment. Complex modeling tasks can be handled with the 'project mode' using DeepView (Swiss-PdbViewer), an integrated sequence-to-structure workbench. All models are sent back via email with a detailed modeling report. WhatCheck analyses and ANOLEA evaluations are provided optionally. The reliability of SWISS-MODEL is continuously evaluated in the EVA-CM project. The SWISS-MODEL server is under constant development to improve the successful implementation of expert knowledge into an easy-to-use server.

PMID:
12824332
[PubMed - indexed for MEDLINE]
PMCID:
PMC168927
Free PMC Article

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