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Immunol Today. 1992 Nov;13(11):431-3.

CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation.

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  • 1Dept of Microbiology, Dartmouth Medical School, Lebanon, NH 03756.

Abstract

The discovery of CD40 and its ligand, gp39, have created new perspectives on the activation of resting B cells by TH cells. Here, Randolph Noelle, Jeffrey Ledbetter and Alejandro Aruffo describe how these molecules were characterized and, from recent findings, examine their relevance to immune activation.

PMID:
1282319
[PubMed - indexed for MEDLINE]
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