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1: Neurology. 2003 Jun 24;60(12):1995-7.Click here to read Links
Comment in:
Neurology. 2004 Aug 10;63(3):597-8; author reply 597-8.

IV amantadine improves chorea in Huntington's disease: an acute randomized, controlled study.

Lucetti C, Del Dotto P, Gambaccini G, Dell' Agnello G, Bernardini S, Rossi G, Murri L, Bonuccelli U.

Department of Neuroscience, University of Pisa, Pisa, Italy.

The acute antidyskinetic effects of IV amantadine in HD were evaluated. A 2-hour IV infusion of amantadine or placebo was administered to nine patients with HD on two different days in a double-blind, randomized crossover fashion. All patients subsequently received oral amantadine unblinded for a 1-year period. A reduction of dyskinesia scores was reported during both IV and oral amantadine treatment (p < 0.05). No significant changes were observed in neuropsychological tests or psychiatric rating scales.

PMID: 12821751 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Amantadine (Symmetrel® , Symmetrel® Syrup)

    Amantadine is used to treat Parkinson's disease and conditions similar to those of Parkinson's disease. It also is used to prevent and treat respiratory infections caused by influenza A virus.

  • Source: AHFS Consumer Medication Information