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Infect Immun. 2003 Jul;71(7):4182-5.

Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae.

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  • 1Program in Human Nutrition, University of Michigan, Ann Arbor, Michigan 48109, USA.

Abstract

Leptin is a pleiotropic hormone-cytokine known to regulate energy homeostasis and immune function. Neutrophils from leptin-deficient mice exhibited impaired phagocytosis of Klebsiella pneumoniae opsonized with serum containing complement and reduced CD11b expression that could be restored with exogenous leptin. These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria.

PMID:
12819114
[PubMed - indexed for MEDLINE]
PMCID:
PMC161963
Free PMC Article
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