Abstract
Based on two lead cytotoxic spongiane diterpenes, a new series of C7-oxygenated derivatives were synthesized and evaluated for their antitumor activity in vitro against the cancer cell lines HeLa and HEp-2. In general, introduction of either hydroxyl or acetoxy groups at C-7 did not improve the resultant cytotoxicity, while the presence of a butyrate ester led to more active compounds (CC(50)=4.0-9.5 microM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Butyrates / chemistry
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Cell Line, Tumor
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Diterpenes / chemical synthesis*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Butyrates
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Diterpenes